Athletes with shoulder pain who practice throwing or overhead activities frequently suffer from shoulder impingement syndrome (SIS). This was a pilot case series. Three consecutive patients with subacromial impingement syndrome in the past 12 months admitted to a sports injury clinic in 2020 were enrolled. They received combination treatment. In addition to the conventional physiotherapy, a 10-minute game-based virtual reality exercise named The clock and balls (Version 2) was used for the rehabilitation program. All three patients completed a total of 20 game-based virtual reality exercise sessions. A comparison of VAS, DASH, and pain thresholds before and after the treatment showed a significant decrease in shoulder pain and disability and a significant increase in patients' pain tolerance threshold. There was also a significant change in shoulder range of motion in the form of increased flexion, extension, abduction, and external rotation. In terms of treatment satisfaction based on a 5-point scale, one patient was completely satisfied with the treatment (score 5), the second expressed good satisfaction (score 4), and the third one was complete satisfaction (score 5).